Determinants of primate neurogenesis and the deployment of top-down generative networks in the cortical hierarchy

What I cannot create do not understand — Richard Feynman 1978 Because primate cortical development exhibits numerous specific features, the mouse is an imperfect model for human development. Expansion of supragranular neurons evolutionary feature characterizing cortex. Increased production supported by a germinal zone innovation cortex: Outer SubVentricular Zone, which along with constitute privileged targets brain-specific gene evolution. The resulting cell-type diversity link cell and molecular changes in progenitors emergence distinctive architectural features We propose that these are required expansion hierarchy deploying top-down generative networks potentially important consequences neurobiology psychiatric disorders.